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Index > Protein center > Mapk14(Gene name) > Rat
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  • Mapk14 (Gene name),
  • Mitogen-activated protein kinase 14 (Protein name ),  MK14_RAT from NCBI database.
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  • Gene name:
    Mapk14(Csbp1;Csbp2);
    Protein name:
    Mitogen-activated protein kinase 14(MAP kinase 14;MAPK 14);
    Alternative:
    Mitogen-activated protein kinase p38 alpha(MAP kinase p38 alpha);CRK1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Binds to a kinase interaction motif within the protein tyrosine phosphatase, PTPRR. This interaction retains MAPK14 in the cytoplasm and prevents nuclear accumulation. Interacts with FAM48A, SPAG9 and NP60.
    Function:
    Responds to activation by environmental stress, pro-inflammatory cytokines and lipopolysaccharide (LPS) by phosphorylating a number of transcription factors, such as ELK1 and ATF2 and several downstream kinases, such as MAPKAPK2 and MAPKAPK5. Plays a critical role in the production of some cytokines, for example IL-6. May play a role in stabilization of EPO during hypoxic stress.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    360
    Sequence:
    50:
    MSQERPTFYR | QELNKTVWEV | PERYQNLSPV | GSGAYGSVCA | AFDTKTGHRV | 
    100:
    AVKKLSRPFQ | SIIHAKRTYR | ELRLLKHMKH | ENVIGLLDVF | TPARSLEEFN | 
    150:
    DVYLVTHLMG | ADLNNIVKCQ | KLTDDHVQFL | IYQILRGLKY | IHSADIIHRD | 
    200:
    LKPSNLAVNE | DCELKILDFG | LARHTDDEMT | GYVATRWYRA | PEIMLNWMHY | 
    250:
    NQTVDIWSVG | CIMAELLTGR | TLFPGTDHID | QLKLILRLVG | TPGAELLKKI | 
    300:
    SSESARNYIQ | SLAQMPKMNF | ANVFIGANPL | AVDLLEKMLV | LDSDKRITAA | 
    350:
    QALAHAYFAQ | YHDPDDEPVA | EPYDQSFESR | DFLIDEWKSL | TYDEVISFVP | 
    360:
    PPLDQEEMES | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat MAP kinase 14
    Cat.:
    E9114h
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    96T
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    ELISA Kit for Rat MAP kinase 14
    MSDS:
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    ELISA Kit for Rat MAP kinase 14
    Cat.:
    E9114m
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    Packing:
    96T
    ELISA Kit for Rat MAP kinase 14
    Cat.:
    E9114r
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    Packing:
    96T
    CLIA Kit for Rat MAP kinase 14
    MSDS:
    Please sign in first.
    CLIA Kit for Rat MAP kinase 14
    Cat.:
    U9114h
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat MAP kinase 14
    Cat.:
    U9114m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat MAP kinase 14
    Cat.:
    U9114r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat MAP kinase 14
    Cat.:
    P9114Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat MAP kinase 14
    Cat.:
    P9114Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat MAP kinase 14
    Polyclonal Antibody for Rat MAP kinase 14
    Monoclonal Antibody for Rat MAP kinase 14
    Monoclonal Antibody for Rat MAP kinase 14
    Monoclonal Antibody for Rat MAP kinase 14
    Monoclonal Antibody for Rat MAP kinase 14
    Protein for Rat MAP kinase 14
    Protein for Rat MAP kinase 14
    Protein for Rat MAP kinase 14
    Protein for Rat MAP kinase 14

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    References
    1. 1.
      "Suppression subtractive hybridization (SSH) identifies prolactin stimulation of p38 MAP kinase gene expression in Nb2 T lymphoma cells: molecular cloning of rat p38 MAP kinase."
      Nemeth E. , Bole-Feysot C. , Tashima L.S.
      J. Mol. Endocrinol.20:151-156(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      Garcia G.E. , Han J. , Feng L.
      Submitted (1997-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: Lewis.
      tissue: Kidney.
    3. 3.
      Reick M.E. , Goldsmith E.J.
      Submitted (2001-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    4. 4.
      "In the cellular garden of forking paths: how p38 MAPKs signal for downstream assistance."
      Shi Y. , Gaestel M.
      Biol. Chem.383:1519-1536(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    5. 5.
      "Mechanisms and functions of p38 MAPK signalling."
      Cuadrado A. , Nebreda A.R.
      Biochem. J.429:403-417(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ENZYME REGULATION;REVIEW ON FUNCTION
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